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Top Health Care Stocks:

JNJ: +0.31%

PFE: Flat

ABT: +0.25%

MRK: +0.49%

AMGN: Flat

Health care giants were mixed in Thursday's pre-market trading .

Early movers include:

(-) Motif Bio ( MTFB ), which was sinking more than 48% after the company said the US Food and Drug Administration will require another clinical trial before granting marketing approval for iclaprim, Motif Bio's product candidate for the treatment of acute bacterial skin and skin structure infections (ABSSSI).

(+) Protalix BioTherapeutics ( PLX ) was up more than 16% after the firm said it plans to file a biologics license application (BLA) for pegunigalsidase alfa in the first quarter for the treatment of Fabry disease.

(+) Seelos Therapeutics ( SEEL ) was more than 4% higher after saying it will meet with the US Food and Drug Administration to design and initiate a proof-of-concept study in patients with post-traumatic stress disorder, or PTSD, at imminent risk of suicide.

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